Bcl-2-related ovarian killer protein (Q9UMX3)

Uniprot ID	Q9UMX3
Protein Name	Bcl-2-related ovarian killer protein
Gene Name	BOK
Species	Homo sapiens (Human)

Signal peptide^(a)	N	Secretome P^(b)	0.835
Function	[Isoform 1]: Apoptosis regulator that functions through different apoptotic signaling pathways (PubMed:27076518, PubMed:15102863, PubMed:20673843). Plays a roles as pro-apoptotic protein that positively regulates intrinsic apoptotic process in a BAX-and BAK1-dependent manner or in a BAX-and BAK1-independent manner (PubMed:27076518, PubMed:15102863). In response to endoplasmic reticulum stress promotes mitochondrial apoptosis through downstream BAX/BAK1 activation and positive regulation of PERK-mediated unfolded protein response (By similarity). Activates apoptosis independently of heterodimerization with survival-promoting BCL2 and BCL2L1 through induction of mitochondrial outer membrane permeabilization, in a BAX-and BAK1-independent manner, in response to inhibition of ERAD-proteasome degradation system, resulting in cytochrome c release (PubMed:27076518). In response to DNA damage, mediates intrinsic apoptotic process in a TP53-dependent manner (PubMed:15102863). Plays a role in granulosa cell apoptosis by CASP3 activation (PubMed:20673843). Plays a roles as anti-apoptotic protein during neuronal apoptotic process, by negatively regulating poly ADP-ribose polymerase-dependent cell death through regulation of neuronal calcium homeostasis and mitochondrial bioenergetics in response to NMDA excitation (By similarity). In addition to its role in apoptosis, may regulate trophoblast cell proliferation during the early stages of placental development, by acting on G1/S transition through regulation of CCNE1 expression (PubMed:19942931). May also play a role as an inducer of autophagy by disrupting interaction between MCL1 and BECN1 (PubMed:24113155). .[Isoform 2]: Pro-apoptotic molecule exerting its function through the mitochondrial pathway. {ECO:0000269\|PubMed:15775999}.
GO - Molecular function	BH domain binding : IEA:Ensembl protein heterodimerization activity : ISS:UniProtKB protein homodimerization activity : ISS:UniProtKB protein-containing complex binding : IEA:Ensembl signaling receptor binding : IEA:Ensembl ubiquitin protein ligase binding : IEA:Ensembl
GO - Biological process	activation of cysteine-type endopeptidase activity involved in apoptotic process : IMP:UniProtKB activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c : ISS:UniProtKB apoptotic process : IDA:UniProtKB brain development : IEA:Ensembl cellular component disassembly involved in execution phase of apoptosis : ISS:UniProtKB extrinsic apoptotic signaling pathway in absence of ligand : IBA:GO_Central intrinsic apoptotic signaling pathway by p53 class mediator : IMP:UniProtKB intrinsic apoptotic signaling pathway in response to DNA damage : IBA:GO_Central male gonad development : IEA:Ensembl negative regulation of mitochondrial depolarization : IEA:Ensembl negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway : IEA:Ensembl negative regulation of necroptotic process : IEA:Ensembl negative regulation of neuron apoptotic process : IEA:Ensembl neuron apoptotic process : IEA:Ensembl oligodendrocyte differentiation : IEA:Ensembl positive regulation of apoptotic process : IDA:UniProtKB positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway : ISS:UniProtKB positive regulation of execution phase of apoptosis : IMP:UniProtKB positive regulation of intrinsic apoptotic signaling pathway : ISS:UniProtKB positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway : ISS:UniProtKB positive regulation of PERK-mediated unfolded protein response : ISS:UniProtKB protein complex oligomerization : ISS:UniProtKB regulation of autophagy : IMP:UniProtKB regulation of chorionic trophoblast cell proliferation : IDA:UniProtKB regulation of cytosolic calcium ion concentration : IEA:Ensembl regulation of granulosa cell apoptotic process : IMP:UniProtKB release of cytochrome c from mitochondria : IDA:UniProtKB

Back

^{(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.}
^{(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.}