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Q9R1T3

Cathepsin Z (Q9R1T3)

Uniprot ID Q9R1T3
Protein Name Cathepsin Z
Gene Name Ctsz
Species Rattus norvegicus (Rat)
Basic Information Experiments (1) Disease (2) Interactions
Signal peptide(a) Y Secretome P(b)
Function Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity (PubMed:12553736, PubMed:10615013). Capable of producing kinin potentiating peptides (PubMed:10615013). .
GO - Molecular function
  • carboxypeptidase activity : ISO:RGD
  • cysteine-type endopeptidase activity : IBA:GO_Central
GO - Biological process
  • epithelial tube branching involved in lung morphogenesis : ISO:RGD
  • negative regulation of neuron projection development : IMP:CAFA
  • negative regulation of plasminogen activation : ISO:RGD
  • negative regulation of protein binding : ISO:RGD
  • positive regulation of neural precursor cell proliferation : IMP:CAFA
  • positive regulation of neuron apoptotic process : IMP:CAFA
  • proteolysis : ISO:RGD
  • proteolysis involved in cellular protein catabolic process : IBA:GO_Central
  • regulation of neuron death : ISO:RGD
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.