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Q9R1T1

Barrier-to-autointegration factor (Q9R1T1)

Uniprot ID Q9R1T1
Protein Name Barrier-to-autointegration factor
Gene Name Banf1
Species Rattus norvegicus (Rat)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b)
Function Plays fundamental roles in nuclear assembly, chromatin organization, gene expression and gonad development. May potently compress chromatin structure and be involved in membrane recruitment and chromatin decondensation during nuclear assembly. Contains 2 non-specific dsDNA-binding sites which may promote DNA cross-bridging. .
GO - Molecular function
  • DNA binding : ISO:RGD
  • enzyme binding : ISO:RGD
  • identical protein binding : IPI:RGD
  • LEM domain binding : ISO:RGD
  • protein C-terminus binding : ISO:RGD
  • protein homodimerization activity : ISO:RGD
  • protein N-terminus binding : ISO:RGD
GO - Biological process
  • chromosome condensation : IBA:GO_Central
  • chromosome segregation : IBA:GO_Central
  • DNA integration : ISO:RGD
  • negative regulation of viral genome replication : ISO:RGD
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.