| Signal peptide(a) |
N |
Secretome P(b) |
0.0 |
| Function |
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase. In kidney development, inhibits tubule formation and bud growth in metanephroi. Inhibits WNT1/WNT4-mediated TCF-dependent transcription. . |
| GO - Molecular function |
- cysteine-type endopeptidase activity : ISO:RGD
- drug binding : ISO:RGD
- frizzled binding : ISO:RGD
- heparin binding : ISO:RGD
- identical protein binding : ISO:RGD
- Wnt-protein binding : ISO:RGD
|
| GO - Biological process |
- anterior/posterior pattern specification : ISO:RGD
- bone trabecula formation : ISO:RGD
- canonical Wnt signaling pathway : ISO:RGD
- cellular response to BMP stimulus : ISO:RGD
- cellular response to estradiol stimulus : ISO:RGD
- cellular response to estrogen stimulus : ISO:RGD
- cellular response to fibroblast growth factor stimulus : ISO:RGD
- cellular response to growth factor stimulus : ISO:RGD
- cellular response to heparin : ISO:RGD
- cellular response to hypoxia : ISO:RGD
- cellular response to interleukin-1 : ISO:RGD
- cellular response to prostaglandin E stimulus : IEP:RGD
- cellular response to starvation : ISO:RGD
- cellular response to transforming growth factor beta stimulus : ISO:RGD
- cellular response to tumor necrosis factor : ISO:RGD
- cellular response to vitamin D : ISO:RGD
- cellular response to X-ray : ISO:RGD
- convergent extension involved in somitogenesis : ISO:RGD
- development of primary male sexual characteristics : ISO:RGD
- digestive tract morphogenesis : ISO:RGD
- dopaminergic neuron differentiation : ISO:RGD
- dorsal/ventral axis specification : ISO:RGD
- female gonad development : ISO:RGD
- hematopoietic progenitor cell differentiation : ISO:RGD
- hematopoietic stem cell differentiation : ISO:RGD
- hemopoiesis : ISO:RGD
- male gonad development : ISO:RGD
- negative regulation of androgen receptor signaling pathway : ISO:RGD
- negative regulation of apoptotic process : ISO:RGD
- negative regulation of B cell differentiation : ISO:RGD
- negative regulation of BMP signaling pathway : ISO:RGD
- negative regulation of bone remodeling : ISO:RGD
- negative regulation of canonical Wnt signaling pathway : IDA:UniProtKB
- negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation : ISO:RGD
- negative regulation of cell growth : ISO:RGD
- negative regulation of cell migration : ISO:RGD
- negative regulation of cell population proliferation : ISO:RGD
- negative regulation of epithelial cell proliferation : ISO:RGD
- negative regulation of epithelial to mesenchymal transition : ISO:RGD
- negative regulation of fibroblast apoptotic process : ISO:RGD
- negative regulation of fibroblast proliferation : ISO:RGD
- negative regulation of gene expression : ISO:RGD
- negative regulation of insulin secretion : ISO:RGD
- negative regulation of JUN kinase activity : ISO:RGD
- negative regulation of ossification : ISO:RGD
- negative regulation of osteoblast differentiation : ISO:RGD
- negative regulation of osteoblast proliferation : ISO:RGD
- negative regulation of osteoclast differentiation : IMP:RGD
- negative regulation of peptidyl-tyrosine phosphorylation : ISO:RGD
- negative regulation of planar cell polarity pathway involved in axis elongation : ISO:RGD
- negative regulation of transcription, DNA-templated : ISO:RGD
- negative regulation of Wnt signaling pathway : IDA:RGD
- negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification : ISO:RGD
- neural crest cell fate commitment : ISO:RGD
- neural tube closure : ISO:RGD
- neural tube development : ISO:RGD
- non-canonical Wnt signaling pathway : IBA:GO_Central
- osteoblast differentiation : IEP:UniProtKB
- planar cell polarity pathway involved in neural tube closure : ISO:RGD
- positive regulation of apoptotic process : ISO:RGD
- positive regulation of canonical Wnt signaling pathway : ISO:RGD
- positive regulation of cell growth : ISO:RGD
- positive regulation of cell population proliferation : ISO:RGD
- positive regulation of epithelial cell proliferation : ISO:RGD
- positive regulation of extrinsic apoptotic signaling pathway : ISO:RGD
- positive regulation of extrinsic apoptotic signaling pathway via death domain receptors : ISO:RGD
- positive regulation of fat cell differentiation : ISO:RGD
- positive regulation of fibroblast apoptotic process : ISO:RGD
- positive regulation of non-canonical Wnt signaling pathway : ISO:RGD
- positive regulation of smoothened signaling pathway : ISO:RGD
- positive regulation of transcription, DNA-templated : ISO:RGD
- positive regulation of Wnt signaling pathway : ISO:RGD
- prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis : ISO:RGD
- regulation of branching involved in prostate gland morphogenesis : ISO:RGD
- regulation of cell cycle process : ISO:RGD
- regulation of establishment of planar polarity : ISO:RGD
- regulation of midbrain dopaminergic neuron differentiation : ISO:RGD
- regulation of neuron projection development : ISO:RGD
- regulation of ossification : IMP:RGD
- response to drug : ISO:RGD
- response to organic cyclic compound : ISO:RGD
- somatic stem cell population maintenance : ISO:RGD
- somitogenesis : ISO:RGD
- stromal-epithelial cell signaling involved in prostate gland development : ISO:RGD
- ureteric bud development : ISO:RGD
- Wnt signaling pathway involved in somitogenesis : ISO:RGD
- Wnt signaling pathway, planar cell polarity pathway : ISO:RGD
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