Ubiquitin carboxyl-terminal hydrolase isozyme L1 (Q9R0P9)

Uniprot ID Q9R0P9
Protein Name Ubiquitin carboxyl-terminal hydrolase isozyme L1
Gene Name Uchl1
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b) 0.629
Function Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity. .
GO - Molecular function
  • alpha-2A adrenergic receptor binding : ISO:MGI
  • cysteine-type endopeptidase activity : ISS:UniProtKB
  • ligase activity : IEA:UniProtKB-KW
  • omega peptidase activity : ISS:UniProtKB
  • thiol-dependent ubiquitin-specific protease activity : IDA:MGI
  • ubiquitin binding : IDA:MGI
  • ubiquitin protein ligase binding : ISO:MGI
GO - Biological process
  • adult walking behavior : IMP:MGI
  • axon target recognition : IMP:MGI
  • axonal transport of mitochondrion : IMP:MGI
  • axonogenesis : IMP:MGI
  • cell proliferation : IMP:MGI
  • eating behavior : IGI:MGI
  • muscle fiber development : IGI:MGI
  • negative regulation of MAP kinase activity : ISO:MGI
  • neuromuscular process : IMP:MGI
  • protein deubiquitination : ISS:UniProtKB
  • response to ischemia : IMP:MGI
  • sensory perception of pain : ISO:MGI
  • ubiquitin-dependent protein catabolic process : ISO:MGI
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.