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Q9R0E1

Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 (Q9R0E1)

Uniprot ID Q9R0E1
Protein Name Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3
Gene Name Plod3
Species Mus musculus (Mouse)
Basic Information Experiments (5) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.569
Function Forms hydroxylysine residues in -Xaa-Lys-Gly-sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links. .
GO - Molecular function
  • iron ion binding : IEA:InterPro
  • L-ascorbic acid binding : IEA:UniProtKB-KW
  • procollagen glucosyltransferase activity : IDA:MGI
  • procollagen-lysine 5-dioxygenase activity : IDA:MGI
GO - Biological process
  • basement membrane assembly : IMP:MGI
  • cellular response to hormone stimulus : IEA:Ensembl
  • collagen fibril organization : IMP:MGI
  • collagen metabolic process : IMP:MGI
  • endothelial cell morphogenesis : IMP:MGI
  • epidermis morphogenesis : IMP:MGI
  • hydroxylysine biosynthetic process : ISO:MGI
  • in utero embryonic development : IMP:MGI
  • lung morphogenesis : IMP:MGI
  • neural tube development : IMP:MGI
  • peptidyl-lysine hydroxylation : IMP:MGI
  • protein localization : IMP:MGI
  • protein O-linked glycosylation : ISO:MGI
  • vasodilation : IMP:MGI
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.