Signal peptide(a) |
N |
Secretome P(b) |
|
Function |
Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus. . |
GO - Molecular function |
- DNA binding : IDA:UniProtKB
- protein domain specific binding : ISO:MGI
|
GO - Biological process |
- cell cycle arrest : ISS:UniProtKB
- myeloid progenitor cell differentiation : IDA:UniProtKB
- regulation of transcription, DNA-templated : IBA:GO_Central
- transcription, DNA-templated : IDA:UniProtKB
|