Myeloid leukemia factor 1 (Q9QWV4)

Uniprot ID Q9QWV4
Protein Name Myeloid leukemia factor 1
Gene Name Mlf1
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b)
Function Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus. .
GO - Molecular function
  • DNA binding : IDA:UniProtKB
  • protein domain specific binding : ISO:MGI
GO - Biological process
  • cell cycle arrest : ISS:UniProtKB
  • myeloid progenitor cell differentiation : IDA:UniProtKB
  • regulation of transcription, DNA-templated : IBA:GO_Central
  • transcription, DNA-templated : IDA:UniProtKB
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.