| Signal peptide(a) |
N |
Secretome P(b) |
0.91 |
| Function |
Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs. By inducing conformational changes in a subset of phosphorylated proteins, acts as a molecular switch in multiple cellular processes. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation (By similarity). Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner (PubMed:17828269). Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation: degradation of FBXW7 leads to subsequent stabilization of JUN (By similarity). May facilitate the ubiquitination and proteasomal degradation of RBBP8/CtIP through CUL3/KLHL15 E3 ubiquitin-protein ligase complex, hence favors DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (By similarity). . |
| GO - Molecular function |
- beta-catenin binding : IPI:ParkinsonsUK-UCL
- GTPase activating protein binding : ISO:MGI
- mitogen-activated protein kinase kinase binding : ISO:MGI
- motor activity : IMP:ParkinsonsUK-UCL
- peptidyl-prolyl cis-trans isomerase activity : IDA:MGI
- phosphoprotein binding : IPI:ARUK-UCL
- phosphoserine residue binding : ISO:MGI
- phosphothreonine residue binding : ISO:MGI
|
| GO - Biological process |
- cell cycle : IEA:UniProtKB-KW
- negative regulation of cell motility : ISO:MGI
- negative regulation of ERK1 and ERK2 cascade : ISO:MGI
- negative regulation of neuron apoptotic process : ISO:MGI
- negative regulation of protein binding : ISO:MGI
- negative regulation of protein catabolic process : ISO:MGI
- negative regulation of transforming growth factor beta receptor signaling pathway : ISO:MGI
- neuron differentiation : IMP:ParkinsonsUK-UCL
- positive regulation of canonical Wnt signaling pathway : ISO:MGI
- positive regulation of cell growth involved in cardiac muscle cell development : ISO:MGI
- positive regulation of GTPase activity : ISO:MGI
- positive regulation of neuron apoptotic process : ISO:MGI
- positive regulation of protein dephosphorylation : ISO:MGI
- positive regulation of protein phosphorylation : ISO:MGI
- positive regulation of transcription by RNA polymerase II : ISO:MGI
- positive regulation of ubiquitin-protein transferase activity : ISO:MGI
- protein stabilization : IMP:ParkinsonsUK-UCL
- regulation of cell proliferation : IMP:MGI
- regulation of cytokinesis : IMP:MGI
- regulation of pathway-restricted SMAD protein phosphorylation : ISO:MGI
- regulation of protein localization to nucleus : ISO:MGI
- synapse organization : IMP:ParkinsonsUK-UCL
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