Signal peptide(a) |
N |
Secretome P(b) |
0.342 |
Function |
Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Binds to activated CDC42 but does not stimulate its GTPase activity (PubMed:16968698). It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth. May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest. . |
GO - Molecular function |
- cadherin binding : ISO:MGI
- calmodulin binding : ISO:MGI
- mitogen-activated protein kinase binding : ISO:MGI
- phosphatidylinositol-3,4,5-trisphosphate binding : ISS:UniProtKB
- protein domain specific binding : ISO:MGI
- protein kinase binding : ISO:MGI
- protein phosphatase binding : ISO:MGI
- protein serine/threonine kinase activator activity : ISO:MGI
- protein-containing complex binding : ISO:MGI
- Rac GTPase binding : IPI:MGI
- Rho GTPase binding : IPI:MGI
- S100 protein binding : ISO:MGI
|
GO - Biological process |
- cellular response to calcium ion : ISO:MGI
- cellular response to epidermal growth factor stimulus : IMP:BHF-UCL
- cellular response to fibroblast growth factor stimulus : IMP:BHF-UCL
- cellular response to platelet-derived growth factor stimulus : IMP:BHF-UCL
- epidermal growth factor receptor signaling pathway : IMP:BHF-UCL
- fibroblast growth factor receptor signaling pathway : IMP:BHF-UCL
- glomerular visceral epithelial cell development : ISS:UniProtKB
- negative regulation of dephosphorylation : IGI:MGI
- neuron projection extension : ISO:MGI
- platelet-derived growth factor receptor signaling pathway : IMP:BHF-UCL
- positive regulation of cellular protein localization : ISO:MGI
- positive regulation of dendrite development : ISO:MGI
- positive regulation of focal adhesion assembly : ISO:MGI
- positive regulation of MAP kinase activity : ISO:MGI
- positive regulation of peptidyl-tyrosine autophosphorylation : ISO:MGI
- positive regulation of protein kinase activity : IMP:BHF-UCL
- positive regulation of vascular associated smooth muscle cell migration : ISO:MGI
- regulation of cytokine production : IMP:MGI
- regulation of GTPase activity : IEA:InterPro
- regulation of mitotic cell cycle : ISS:UniProtKB
- response to angiotensin : IEA:Ensembl
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