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Q9JII6

Alcohol dehydrogenase [NADP(+)] (Q9JII6)

Uniprot ID Q9JII6
Protein Name Alcohol dehydrogenase [NADP(+)]
Gene Name Akr1a1
Species Mus musculus (Mouse)
Basic Information Experiments (3) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.779
Function Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs (By similarity). .
GO - Molecular function
  • alcohol dehydrogenase (NADP+) activity : NAS:UniProtKB
  • alditol : IDA:MGI
  • L-glucuronate reductase activity : IDA:MGI
GO - Biological process
  • aldehyde catabolic process : IDA:MGI
  • D-glucuronate catabolic process : IDA:MGI
  • L-ascorbic acid biosynthetic process : IDA:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.