Ran guanine nucleotide release factor (Q9JIB0)

Uniprot ID Q9JIB0
Protein Name Ran guanine nucleotide release factor
Gene Name Rangrf
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b)
Function May regulate the intracellular trafficking of RAN (PubMed:10811801, PubMed:11733047). Promotes guanine nucleotide release from RAN and inhibits binding of new GTP by preventing the binding of the RAN guanine nucleotide exchange factor RCC1 (PubMed:10811801, PubMed:11733047). Regulates the levels of GTP-bound RAN in the nucleus, and thereby plays a role in the regulation of RAN-dependent mitotic spindle dynamics (By similarity). Enhances the expression of SCN5A at the cell membrane in cardiomyocytes (PubMed:18184654, PubMed:23420830). .
GO - Molecular function
  • guanyl-nucleotide exchange factor activity : IDA:MGI
  • ion channel binding : IPI:BHF-UCL
  • Ran GTPase binding : IDA:MGI
  • Ran guanyl-nucleotide exchange factor activity : IDA:MGI
  • sodium channel regulator activity : IMP:BHF-UCL
GO - Biological process
  • endoplasmic reticulum to Golgi vesicle-mediated transport : ISO:MGI
  • nucleocytoplasmic transport : TAS:MGI
  • positive regulation of protein localization to cell surface : ISO:MGI
  • positive regulation of protein localization to plasma membrane : ISO:MGI
  • protein exit from endoplasmic reticulum : ISO:MGI
  • regulation of bundle of His cell action potential : ISO:MGI
  • regulation of cardiac muscle cell action potential involved in regulation of contraction : ISO:MGI
  • regulation of membrane depolarization : IMP:BHF-UCL
  • regulation of membrane depolarization during cardiac muscle cell action potential : ISO:MGI
  • regulation of membrane potential : ISO:MGI
  • regulation of microtubule nucleation by Ran protein signal transduction : ISO:MGI
  • regulation of sodium ion transmembrane transport : IMP:BHF-UCL
  • regulation of sodium ion transmembrane transporter activity : IMP:BHF-UCL
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.