Signal peptide(a) |
N |
Secretome P(b) |
|
Function |
May regulate the intracellular trafficking of RAN (PubMed:10811801, PubMed:11733047). Promotes guanine nucleotide release from RAN and inhibits binding of new GTP by preventing the binding of the RAN guanine nucleotide exchange factor RCC1 (PubMed:10811801, PubMed:11733047). Regulates the levels of GTP-bound RAN in the nucleus, and thereby plays a role in the regulation of RAN-dependent mitotic spindle dynamics (By similarity). Enhances the expression of SCN5A at the cell membrane in cardiomyocytes (PubMed:18184654, PubMed:23420830). . |
GO - Molecular function |
- guanyl-nucleotide exchange factor activity : IDA:MGI
- ion channel binding : IPI:BHF-UCL
- Ran GTPase binding : IDA:MGI
- Ran guanyl-nucleotide exchange factor activity : IDA:MGI
- sodium channel regulator activity : IMP:BHF-UCL
|
GO - Biological process |
- endoplasmic reticulum to Golgi vesicle-mediated transport : ISO:MGI
- nucleocytoplasmic transport : TAS:MGI
- positive regulation of protein localization to cell surface : ISO:MGI
- positive regulation of protein localization to plasma membrane : ISO:MGI
- protein exit from endoplasmic reticulum : ISO:MGI
- regulation of bundle of His cell action potential : ISO:MGI
- regulation of cardiac muscle cell action potential involved in regulation of contraction : ISO:MGI
- regulation of membrane depolarization : IMP:BHF-UCL
- regulation of membrane depolarization during cardiac muscle cell action potential : ISO:MGI
- regulation of membrane potential : ISO:MGI
- regulation of microtubule nucleation by Ran protein signal transduction : ISO:MGI
- regulation of sodium ion transmembrane transport : IMP:BHF-UCL
- regulation of sodium ion transmembrane transporter activity : IMP:BHF-UCL
|