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Q9JHU4

Cytoplasmic dynein 1 heavy chain 1 (Q9JHU4)

Uniprot ID Q9JHU4
Protein Name Cytoplasmic dynein 1 heavy chain 1
Gene Name Dync1h1
Species Mus musculus (Mouse)
Basic Information Experiments (2) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.0
Function Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression. .
GO - Molecular function
  • ATP binding : IEA:UniProtKB-KW
  • ATP-dependent microtubule motor activity, minus-end-directed : IBA:GO_Central
  • dynein intermediate chain binding : IBA:GO_Central
  • dynein light chain binding : IBA:GO_Central
  • dynein light intermediate chain binding : IPI:MGI
  • ATP binding : IEA:UniProtKB-KW
  • ATP-dependent microtubule motor activity, minus-end-directed : IBA:GO_Central
  • dynein intermediate chain binding : IBA:GO_Central
  • dynein light chain binding : IBA:GO_Central
  • dynein light intermediate chain binding : IPI:MGI
GO - Biological process
  • cell division : IEA:UniProtKB-KW
  • cilium movement : IC:MGI
  • cytoplasmic microtubule organization : IBA:GO_Central
  • cytoplasmic mRNA processing body assembly : IMP:BHF-UCL
  • establishment of spindle localization : ISO:MGI
  • minus-end-directed vesicle transport along microtubule : IBA:GO_Central
  • positive regulation of intracellular transport : ISS:UniProtKB
  • positive regulation of spindle assembly : ISS:UniProtKB
  • regulation of metaphase plate congression : ISS:UniProtKB
  • regulation of mitotic spindle organization : ISS:UniProtKB
  • stress granule assembly : IMP:BHF-UCL
  • cell division : IEA:UniProtKB-KW
  • cilium movement : IC:MGI
  • cytoplasmic microtubule organization : IBA:GO_Central
  • cytoplasmic mRNA processing body assembly : IMP:BHF-UCL
  • establishment of spindle localization : ISO:MGI
  • minus-end-directed vesicle transport along microtubule : IBA:GO_Central
  • positive regulation of intracellular transport : ISS:UniProtKB
  • positive regulation of spindle assembly : ISS:UniProtKB
  • regulation of metaphase plate congression : ISS:UniProtKB
  • regulation of mitotic spindle organization : ISS:UniProtKB
  • stress granule assembly : IMP:BHF-UCL
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.