| Signal peptide(a) |
N |
Secretome P(b) |
0.0 |
| Function |
Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP (By similarity). . |
| GO - Molecular function |
- amyloid-beta binding : ISO:MGI
- ATP binding : ISS:UniProtKB
- ATPase activity : ISO:MGI
- beta-endorphin binding : ISO:MGI
- identical protein binding : ISO:MGI
- insulin binding : ISO:MGI
- metalloendopeptidase activity : ISS:UniProtKB
- peptide binding : ISO:MGI
- peptide hormone binding : ISO:MGI
- protein homodimerization activity : ISO:MGI
- signaling receptor binding : ISO:MGI
- ubiquitin-dependent protein binding : ISO:MGI
- zinc ion binding : ISS:UniProtKB
|
| GO - Biological process |
- amyloid-beta clearance : ISO:MGI
- amyloid-beta metabolic process : ISS:UniProtKB
- bradykinin catabolic process : ISS:UniProtKB
- cellular protein catabolic process : ISO:MGI
- determination of adult lifespan : ISO:MGI
- hormone catabolic process : ISO:MGI
- insulin catabolic process : ISO:MGI
- insulin metabolic process : ISO:MGI
- negative regulation of proteolysis : ISO:MGI
- positive regulation of protein oligomerization : ISO:MGI
- protein heterooligomerization : ISO:MGI
- protein homooligomerization : ISO:MGI
- protein homotetramerization : ISO:MGI
- proteolysis : ISO:MGI
- proteolysis involved in cellular protein catabolic process : ISO:MGI
- ubiquitin recycling : ISO:MGI
|