Pleckstrin (Q9JHK5)

Uniprot ID Q9JHK5
Protein Name Pleckstrin
Gene Name Plek
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b) 0.619
Function Major protein kinase C substrate of platelets.
GO - Molecular function
  • phosphatidylinositol-3,4-bisphosphate binding : ISO:MGI
  • protein homodimerization activity : ISO:MGI
  • protein kinase C binding : ISO:MGI
GO - Biological process
  • actin cytoskeleton reorganization : ISO:MGI
  • cell projection organization : ISO:MGI
  • cortical actin cytoskeleton organization : ISO:MGI
  • hematopoietic progenitor cell differentiation : IEA:Ensembl
  • integrin-mediated signaling pathway : ISO:MGI
  • negative regulation of G-protein coupled receptor protein signaling pathway : ISO:MGI
  • negative regulation of inositol phosphate biosynthetic process : ISO:MGI
  • phosphatidylinositol metabolic process : ISO:MGI
  • phospholipase C-inhibiting G-protein coupled receptor signaling pathway : ISO:MGI
  • platelet aggregation : IMP:BHF-UCL
  • positive regulation of actin filament bundle assembly : ISO:MGI
  • positive regulation of actin filament depolymerization : IMP:BHF-UCL
  • positive regulation of inositol-polyphosphate 5-phosphatase activity : ISO:MGI
  • positive regulation of integrin activation : IMP:BHF-UCL
  • positive regulation of platelet activation : IMP:BHF-UCL
  • protein kinase C signaling : IMP:BHF-UCL
  • protein secretion by platelet : IMP:BHF-UCL
  • regulation of cell diameter : ISO:MGI
  • ruffle organization : ISO:MGI
  • thrombin-activated receptor signaling pathway : IMP:BHF-UCL
  • vesicle docking involved in exocytosis : IMP:BHF-UCL
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.