CCN family member 1 (Q9ES72)

Uniprot ID	Q9ES72
Protein Name	CCN family member 1
Gene Name	Ccn1
Species	Rattus norvegicus (Rat)

Signal peptide^(a)	Y	Secretome P^(b)	0.0
Function	Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5 (By similarity). CCN1-mediated gene regulation is dependent on heparin-binding (By similarity). Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1 (By similarity). Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-1/beta-5 and cell proliferation through integrin alpha-v/beta-3 (By similarity). .
GO - Molecular function	extracellular matrix binding : ISO:RGD heparin binding : IBA:GO_Central insulin-like growth factor binding : IEA:InterPro integrin binding : ISO:RGD
GO - Biological process	apoptotic process involved in heart morphogenesis : ISO:RGD atrial septum morphogenesis : ISO:RGD atrioventricular valve morphogenesis : ISO:RGD cell adhesion : IDA:RGD cell-cell adhesion : ISO:RGD chemotaxis : IDA:RGD chondroblast differentiation : ISO:RGD chorio-allantoic fusion : ISO:RGD extracellular matrix organization : ISO:RGD intussusceptive angiogenesis : ISO:RGD labyrinthine layer blood vessel development : ISO:RGD negative regulation of apoptotic process : ISO:RGD negative regulation of cell death : IBA:GO_Central osteoblast differentiation : ISO:RGD positive regulation of angiogenesis : TAS:RGD positive regulation of apoptotic process : ISO:RGD positive regulation of BMP signaling pathway : ISO:RGD positive regulation of bone mineralization : ISO:RGD positive regulation of cartilage development : ISO:RGD positive regulation of cell differentiation : ISO:RGD positive regulation of cell migration : ISO:RGD positive regulation of cell-substrate adhesion : ISO:RGD positive regulation of ceramide biosynthetic process : ISO:RGD positive regulation of cysteine-type endopeptidase activity involved in apoptotic process : ISO:RGD positive regulation of osteoblast differentiation : ISO:RGD positive regulation of osteoblast proliferation : ISO:RGD positive regulation of phospholipase activity : ISO:RGD positive regulation of protein kinase activity : ISO:RGD positive regulation of protein phosphorylation : ISO:RGD positive regulation of transcription by RNA polymerase II : ISO:RGD reactive oxygen species metabolic process : ISO:RGD regulation of ERK1 and ERK2 cascade : ISO:RGD ventricular septum development : ISO:RGD wound healing, spreading of cells : ISO:RGD

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^{(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.}
^{(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.}