Nuclear protein localization protein 4 homolog (Q9ES54)

Uniprot ID Q9ES54
Protein Name Nuclear protein localization protein 4 homolog
Gene Name Nploc4
Species Rattus norvegicus (Rat)
Signal peptide(a) N Secretome P(b)
Function The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (PubMed:10811609, PubMed:11740563, PubMed:11781570, PubMed:12411482, PubMed:12644454, PubMed:14636562). Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I (By similarity). .
GO - Molecular function
  • ATPase binding : IPI:ParkinsonsUK-UCL
  • metal ion binding : IEA:UniProtKB-KW
  • protein-containing complex binding : IPI:RGD
  • ubiquitin binding : IDA:BHF-UCL
  • ubiquitin protein ligase binding : IDA:BHF-UCL
GO - Biological process
  • Golgi organization : IDA:HGNC-UCL
  • negative regulation of RIG-I signaling pathway : ISS:UniProtKB
  • negative regulation of type I interferon production : ISS:UniProtKB
  • proteasome-mediated ubiquitin-dependent protein catabolic process : IEA:UniProtKB-UniPathway
  • retrograde protein transport, ER to cytosol : ISS:ParkinsonsUK-UCL
  • ubiquitin-dependent protein catabolic process : ISS:UniProtKB
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.