Importin-7 (Q9EPL8)

Uniprot ID Q9EPL8
Protein Name Importin-7
Gene Name Ipo7
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b) 0.599
Function Functions in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with KPNB1 mediates the nuclear import of H1 histone and the Ran-binding site of IPO7 is not required but synergizes with that of KPNB1 in importin/substrate complex dissociation (By similarity). In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. .
GO - Molecular function
  • histone binding : IDA:MGI
  • protein transporter activity : IBA:GO_Central
  • Ran GTPase binding : IEA:InterPro
  • SMAD binding : ISO:MGI
GO - Biological process
  • innate immune response : IMP:MGI
  • protein import into nucleus : IDA:MGI
  • signal transduction : IBA:GO_Central
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.