| Signal peptide(a) |
N |
Secretome P(b) |
|
| Function |
In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (By similarity). Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (PubMed:16707451). Acts as a co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1 (PubMed:29127155). Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 ATPase activity (PubMed:29127155). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (By similarity). Recruits TSC2 to HSP90AA1 and stabilizes TSC2 by preventing the interaction between TSC2 and ubiquitin ligase HERC1 (By similarity). . |
| GO - Molecular function |
- ATPase inhibitor activity : IMP:UniProtKB
- chaperone binding : ISO:MGI
- GTPase activating protein binding : ISO:MGI
- Hsp70 protein binding : ISO:MGI
- Hsp90 protein binding : ISO:MGI
- protein N-terminus binding : IPI:UniProtKB
- protein-containing complex binding : ISO:MGI
|
| GO - Biological process |
- activation of GTPase activity : ISO:MGI
- adaptive immune response : IMP:MGI
- adult locomotory behavior : ISS:ParkinsonsUK-UCL
- cardiac muscle cell differentiation : IMP:MGI
- cell projection organization : IMP:MGI
- cell-matrix adhesion : ISO:MGI
- cellular response to oxygen-glucose deprivation : ISS:ParkinsonsUK-UCL
- cerebral cortex development : IMP:MGI
- glucose import : IMP:MGI
- hippocampus development : IMP:MGI
- kidney development : IMP:MGI
- memory T cell differentiation : IMP:MGI
- myelination : IMP:MGI
- negative regulation of ATPase activity : IMP:UniProtKB
- negative regulation of cell population proliferation : IMP:MGI
- negative regulation of cell size : IMP:MGI
- negative regulation of GTPase activity : ISO:MGI
- negative regulation of insulin receptor signaling pathway : IBA:GO_Central
- negative regulation of macroautophagy : ISS:ParkinsonsUK-UCL
- negative regulation of neuron projection development : ISO:MGI
- negative regulation of oxidative stress-induced neuron death : ISO:MGI
- negative regulation of TOR signaling : ISS:ParkinsonsUK-UCL
- negative regulation of translation : ISO:MGI
- nervous system development : IMP:MGI
- neural tube closure : IMP:MGI
- positive regulation of focal adhesion assembly : ISO:MGI
- positive regulation of macroautophagy : ISO:MGI
- positive regulation of stress fiber assembly : ISO:MGI
- potassium ion transport : IMP:MGI
- protein heterooligomerization : IEA:Ensembl
- protein stabilization : IMP:UniProtKB
- regulation of cell cycle : IBA:GO_Central
- regulation of cell-matrix adhesion : ISO:MGI
- regulation of focal adhesion assembly : ISO:MGI
- regulation of neuron death : ISS:ParkinsonsUK-UCL
- regulation of phosphoprotein phosphatase activity : ISO:MGI
- regulation of protein kinase activity : IGI:MGI
- regulation of stress fiber assembly : ISO:MGI
- regulation of translation : ISO:MGI
- response to insulin : ISO:MGI
- rRNA export from nucleus : ISO:MGI
- synapse organization : IMP:MGI
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