Myotrophin (Q9DCN8)

Uniprot ID Q9DCN8
Protein Name Myotrophin
Gene Name Mtpn
Species Rattus norvegicus (Rat)
Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b)
Function Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer (By similarity). Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy. .
GO - Molecular function
  • sequence-specific DNA binding : IDA:RGD
  • sequence-specific DNA binding : ISO:MGI
GO - Biological process
  • catecholamine metabolic process : IEP:RGD
  • cellular response to mechanical stimulus : IEP:RGD
  • cerebellar granule cell differentiation : IEP:RGD
  • neuron differentiation : NAS:UniProtKB
  • positive regulation of cardiac muscle hypertrophy : IMP:UniProtKB
  • positive regulation of cell growth : IDA:UniProtKB
  • positive regulation of macromolecule biosynthetic process : IDA:UniProtKB
  • positive regulation of NF-kappaB transcription factor activity : IDA:UniProtKB
  • positive regulation of protein metabolic process : IDA:UniProtKB
  • regulation of barbed-end actin filament capping : ISS:UniProtKB
  • regulation of cell size : ISO:RGD
  • skeletal muscle tissue regeneration : IEP:RGD
  • striated muscle cell differentiation : IEP:RGD
  • catecholamine metabolic process : IEA:Ensembl
  • cellular response to mechanical stimulus : IEA:Ensembl
  • cerebellar granule cell differentiation : IEA:Ensembl
  • positive regulation of cardiac muscle hypertrophy : ISS:UniProtKB
  • positive regulation of cell growth : ISS:UniProtKB
  • positive regulation of macromolecule biosynthetic process : ISS:UniProtKB
  • positive regulation of NF-kappaB transcription factor activity : ISS:UniProtKB
  • positive regulation of protein metabolic process : ISS:UniProtKB
  • regulation of barbed-end actin filament capping : ISS:UniProtKB
  • regulation of cell size : ISO:MGI
  • skeletal muscle tissue regeneration : IEA:Ensembl
  • striated muscle cell differentiation : IEA:Ensembl
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.