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Q9D2G2

Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (Q9D2G2)

Uniprot ID Q9D2G2
Protein Name Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
Gene Name Dlst
Species Mus musculus (Mouse)
Basic Information Experiments (0) Disease (0) Interactions
Signal peptide(a) N Secretome P(b)
Function Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex (By similarity). The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) (By similarity). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (By similarity). .
GO - Molecular function
  • chaperone binding : ISO:MGI
  • dihydrolipoyllysine-residue succinyltransferase activity : ISS:UniProtKB
  • heat shock protein binding : ISO:MGI
GO - Biological process
  • 2-oxoglutarate metabolic process : ISS:UniProtKB
  • histone succinylation : ISS:UniProtKB
  • L-lysine catabolic process to acetyl-CoA via saccharopine : IEA:UniProtKB-UniPathway
  • NADH metabolic process : ISO:MGI
  • succinyl-CoA metabolic process : ISS:UniProtKB
  • tricarboxylic acid cycle : IEA:UniProtKB-KW
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.