Cysteine and histidine-rich domain-containing protein 1 (Q9D1P4)

Uniprot ID Q9D1P4
Protein Name Cysteine and histidine-rich domain-containing protein 1
Gene Name Chordc1
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b) 0.591
Function Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone complex. In vitro, has intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1. Involved in stress response. Prevents tumorigenesis (By similarity). .
GO - Molecular function
  • ADP binding : IDA:MGI
  • ATP binding : IDA:MGI
  • Hsp90 protein binding : ISO:MGI
  • zinc ion binding : IDA:MGI
GO - Biological process
  • chaperone-mediated protein folding : IDA:UniProtKB
  • negative regulation of Rho-dependent protein serine/threonine kinase activity : IDA:UniProtKB
  • regulation of cellular response to heat : IDA:UniProtKB
  • regulation of centrosome duplication : IMP:UniProtKB
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.