Signal peptide(a) |
N |
Secretome P(b) |
0.591 |
Function |
Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone complex. In vitro, has intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1. Involved in stress response. Prevents tumorigenesis (By similarity). . |
GO - Molecular function |
- ADP binding : IDA:MGI
- ATP binding : IDA:MGI
- Hsp90 protein binding : ISO:MGI
- zinc ion binding : IDA:MGI
|
GO - Biological process |
- chaperone-mediated protein folding : IDA:UniProtKB
- negative regulation of Rho-dependent protein serine/threonine kinase activity : IDA:UniProtKB
- regulation of cellular response to heat : IDA:UniProtKB
- regulation of centrosome duplication : IMP:UniProtKB
|