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Q9CYN9

Renin receptor (Q9CYN9)

Uniprot ID Q9CYN9
Protein Name Renin receptor
Gene Name Atp6ap2
Species Mus musculus (Mouse)
Basic Information Experiments (4) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.646
Function Functions as a renin and prorenin cellular receptor. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, it may also play a role in the renin-angiotensin system (RAS) (By similarity). .
GO - Molecular function
  • enzyme binding : ISO:MGI
  • signaling receptor activity : IEA:InterPro
GO - Biological process
  • angiotensin maturation : ISO:MGI
  • eye pigmentation : ISO:MGI
  • head morphogenesis : ISO:MGI
  • positive regulation of transforming growth factor beta1 production : ISO:MGI
  • positive regulation of Wnt signaling pathway : IMP:UniProtKB
  • regulation of MAPK cascade : ISO:MGI
  • rostrocaudal neural tube patterning : ISO:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.