Calcyclin-binding protein (Q9CXW3)

Uniprot ID Q9CXW3
Protein Name Calcyclin-binding protein
Gene Name Cacybp
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b) 0.775
Function May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1) (By similarity). .
GO - Molecular function
  • protein domain specific binding : IPI:CAFA
  • protein homodimerization activity : ISO:MGI
  • S100 protein binding : IEA:InterPro
  • tubulin binding : IEA:InterPro
  • ubiquitin protein ligase binding : IPI:CAFA
GO - Biological process
  • aging : IEA:Ensembl
  • cardiac muscle cell differentiation : ISO:MGI
  • cellular response to calcium ion : IEA:Ensembl
  • cellular response to leukemia inhibitory factor : IEP:MGI
  • negative regulation of cell death : ISO:MGI
  • positive regulation of DNA replication : ISO:MGI
  • response to growth hormone : ISO:MGI
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.