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Q9CWJ9

Bifunctional purine biosynthesis protein PURH (Q9CWJ9)

Uniprot ID Q9CWJ9
Protein Name Bifunctional purine biosynthesis protein PURH
Gene Name Atic
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.679
Function Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis. .Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization. {ECO:0000250|UniProtKB:P31939}.
GO - Molecular function
  • cadherin binding : ISO:MGI
  • IMP cyclohydrolase activity : ISO:MGI
  • phosphoribosylaminoimidazolecarboxamide formyltransferase activity : ISO:MGI
  • protein homodimerization activity : ISS:UniProtKB
GO - Biological process
  • 'de novo' IMP biosynthetic process : ISO:MGI
  • animal organ regeneration : IEA:Ensembl
  • brainstem development : IEA:Ensembl
  • cerebellum development : IEA:Ensembl
  • cerebral cortex development : IEA:Ensembl
  • dihydrofolate metabolic process : ISO:MGI
  • nucleoside metabolic process : ISO:MGI
  • response to inorganic substance : IEA:Ensembl
  • ribonucleotide metabolic process : ISO:MGI
  • tetrahydrofolate biosynthetic process : ISO:MGI
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.