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Q9CW03

Structural maintenance of chromosomes protein 3 (Q9CW03)

Uniprot ID Q9CW03
Protein Name Structural maintenance of chromosomes protein 3
Gene Name Smc3
Species Mus musculus (Mouse)
Basic Information Experiments (2) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.192
Function Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex plays also an important role in spindle pole assembly during mitosis and in chromosomes movement. .
GO - Molecular function
  • ATP binding : IEA:UniProtKB-KW
  • beta-tubulin binding : ISO:MGI
  • chromatin binding : IDA:MGI
  • dynein complex binding : ISS:UniProtKB
  • mediator complex binding : IDA:MGI
  • protein heterodimerization activity : ISO:MGI
  • protein-containing complex binding : IDA:CAFA
GO - Biological process
  • cell division : IEA:UniProtKB-KW
  • DNA repair : IEA:UniProtKB-KW
  • interaction with symbiont : ISO:MGI
  • meiotic cell cycle : IPI:MGI
  • negative regulation of DNA endoreduplication : ISO:MGI
  • positive regulation by host of viral release from host cell : ISO:MGI
  • regulation of DNA replication : ISS:UniProtKB
  • regulation of mitotic spindle assembly : ISO:MGI
  • sister chromatid cohesion : ISO:MGI
  • stem cell population maintenance : IMP:MGI
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.