Desumoylating isopeptidase 1 (Q9CQT7)

Uniprot ID Q9CQT7
Protein Name Desumoylating isopeptidase 1
Gene Name Desi1
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b)
Function Protease which deconjugates SUMO1, SUMO2 and SUMO3 from some substrate proteins (PubMed:22370726, PubMed:22498933). Has isopeptidase but not SUMO-processing activity (PubMed:22370726, PubMed:22498933). Desumoylates ZBTB46 (PubMed:22370726). Collaborates with UBQLN4 in the export of ubiquitinated proteins from the nucleus to the cytoplasm (By similarity). .
GO - Molecular function
  • identical protein binding : IPI:IntAct
  • peptidase activity : IEA:UniProtKB-KW
GO - Biological process
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.