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Q9CPU0

Lactoylglutathione lyase (Q9CPU0)

Uniprot ID Q9CPU0
Protein Name Lactoylglutathione lyase
Gene Name Glo1
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (8) Interactions
Signal peptide(a) N Secretome P(b) 0.707
Function Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B. Required for normal osteoclastogenesis. .
GO - Molecular function
  • lactoylglutathione lyase activity : IDA:UniProtKB
  • zinc ion binding : IDA:UniProtKB
GO - Biological process
  • carbohydrate metabolic process : ISO:MGI
  • glutathione metabolic process : ISO:MGI
  • methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione : IC:MGI
  • methylglyoxal metabolic process : ISO:MGI
  • negative regulation of apoptotic process : ISS:UniProtKB
  • osteoclast differentiation : IMP:UniProtKB
  • regulation of transcription by RNA polymerase II : IDA:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.