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Q99NH8

Triggering receptor expressed on myeloid cells 2 (Q99NH8)

Uniprot ID Q99NH8
Protein Name Triggering receptor expressed on myeloid cells 2
Gene Name Trem2
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (14) Interactions
Signal peptide(a) Y Secretome P(b) 0.224
Function Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. .
GO - Molecular function
  • lipopolysaccharide binding : IDA:BHF-UCL
  • lipoteichoic acid binding : IDA:BHF-UCL
  • peptidoglycan binding : IDA:BHF-UCL
  • phospholipid binding : ISS:UniProtKB
  • scaffold protein binding : ISO:MGI
  • transmembrane signaling receptor activity : ISS:MGI
GO - Biological process
  • cellular response to lipoteichoic acid : IDA:BHF-UCL
  • cellular response to peptidoglycan : IDA:BHF-UCL
  • dendritic cell differentiation : ISO:MGI
  • detection of lipopolysaccharide : IDA:BHF-UCL
  • detection of lipoteichoic acid : IDA:BHF-UCL
  • detection of peptidoglycan : IDA:BHF-UCL
  • innate immune response : IC:BHF-UCL
  • lipopolysaccharide-mediated signaling pathway : IC:BHF-UCL
  • osteoclast differentiation : ISO:MGI
  • phagocytosis, engulfment : IDA:MGI
  • positive regulation of antigen processing and presentation of peptide antigen via MHC class II : ISO:MGI
  • positive regulation of C-C chemokine receptor CCR7 signaling pathway : ISO:MGI
  • positive regulation of calcium-mediated signaling : ISO:MGI
  • positive regulation of CD40 signaling pathway : ISO:MGI
  • positive regulation of ERK1 and ERK2 cascade : ISS:UniProtKB
  • positive regulation of peptidyl-tyrosine phosphorylation : ISO:MGI
  • positive regulation of protein localization to plasma membrane : ISO:MGI
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.