Collagen, type VIII, alpha 1 (Q9598)

Uniprot ID	Q9598
Protein Name	Collagen, type VIII, alpha 1
Gene Name	ADIM
Species	Pan troglodytes (Chimpanzee)

Signal peptide^(a)	Y	Secretome P^(b)
Function
GO - Molecular function	identical protein binding : IEA:Ensembl protein homodimerization activity : IEA:Ensembl extracellular matrix structural constituent : IBA:GO_Central hormone activity : IBA:GO_Central identical protein binding : IEA:Ensembl identical protein binding : IEA:Ensembl signaling receptor binding : IEA:Ensembl identical protein binding : IEA:Ensembl signaling receptor binding : IEA:Ensembl hormone activity : IBA:GO_Central protein homodimerization activity : IEA:Ensembl extracellular matrix structural constituent : IBA:GO_Central identical protein binding : IEA:Ensembl protein homodimerization activity : IEA:Ensembl calcium ion binding : IEA:Ensembl extracellular matrix structural constituent : IBA:GO_Central signaling receptor binding : IEA:Ensembl collagen binding : IEA:Ensembl identical protein binding : IEA:Ensembl extracellular matrix structural constituent : IBA:GO_Central identical protein binding : IEA:Ensembl hormone activity : IEA:Ensembl protein homodimerization activity : IEA:Ensembl sialic acid binding : IEA:Ensembl
GO - Biological process	complement activation, classical pathway : IEA:InterPro complement activation, classical pathway : IEA:InterPro complement activation, classical pathway : IEA:InterPro complement activation, classical pathway : IEA:InterPro inner ear development : IEA:Ensembl synapse pruning : IEA:Ensembl camera-type eye morphogenesis : IEA:Ensembl epithelial cell proliferation : IEA:Ensembl extracellular matrix organization : IBA:GO_Central complement activation, classical pathway : IEA:InterPro complement activation, classical pathway : IEA:InterPro aging : IEA:Ensembl astrocyte activation : IEA:Ensembl complement activation, classical pathway : IEA:Ensembl complement-mediated synapse pruning : IEA:Ensembl microglial cell activation : IEA:Ensembl neuron remodeling : IEA:Ensembl positive regulation of neuron death : IEA:Ensembl vertebrate eye-specific patterning : IEA:Ensembl protein secretion : IEA:Ensembl negative regulation of gluconeogenesis : IBA:GO_Central negative regulation of inflammatory response : IEA:Ensembl positive regulation of glucose import : IBA:GO_Central positive regulation of insulin receptor signaling pathway : IBA:GO_Central positive regulation of insulin secretion involved in cellular response to glucose stimulus : IEA:Ensembl positive regulation of protein kinase B signaling : IEA:Ensembl regulation of glucose metabolic process : IBA:GO_Central regulation of synapse organization : IEA:Ensembl positive regulation of cell motility : IEA:Ensembl maintenance of synapse structure : IEA:Ensembl motor learning : IEA:Ensembl neuron remodeling : IEA:Ensembl activation of MAPK activity : IEA:Ensembl positive regulation of fatty acid oxidation : IEA:Ensembl positive regulation of glucose import : IEA:Ensembl positive regulation of glycogen biosynthetic process : IEA:Ensembl cellular iron ion homeostasis : IEA:Ensembl negative regulation of gluconeogenesis : IBA:GO_Central positive regulation of fatty acid transport : IEA:Ensembl positive regulation of glucose import : IBA:GO_Central positive regulation of insulin receptor signaling pathway : IBA:GO_Central regulation of fatty acid metabolic process : IEA:Ensembl regulation of glucose metabolic process : IBA:GO_Central extracellular matrix organization : IBA:GO_Central positive regulation of synapse assembly : IEA:Ensembl regulation of presynapse assembly : IEA:Ensembl negative regulation of ERK1 and ERK2 cascade : IEA:Ensembl negative regulation of fat cell differentiation : IEA:Ensembl negative regulation of fibroblast proliferation : IEA:Ensembl cerebellar granule cell differentiation : IEA:Ensembl heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules : IEA:Ensembl negative regulation of excitatory postsynaptic potential : IEA:Ensembl positive regulation of long-term synaptic depression : IEA:Ensembl positive regulation of synapse assembly : IEA:Ensembl protein secretion : IEA:Ensembl regulation of postsynaptic density assembly : IEA:Ensembl regulation of presynapse assembly : IEA:Ensembl extracellular matrix organization : IBA:GO_Central otolith mineralization : IEA:Ensembl protein homooligomerization : IEA:Ensembl negative regulation of cell growth : IEA:Ensembl positive regulation of canonical Wnt signaling pathway : IEA:Ensembl positive regulation of dendritic spine morphogenesis : IEA:Ensembl positive regulation of peptidyl-serine phosphorylation : IEA:Ensembl positive regulation of protein binding : IEA:Ensembl positive regulation of transcription by RNA polymerase II : IEA:Ensembl negative regulation of platelet aggregation : IEA:Ensembl positive regulation of aldosterone secretion : IEA:Ensembl positive regulation of cytosolic calcium ion concentration : IEA:Ensembl positive regulation of gene expression : IEA:Ensembl positive regulation of MAPK cascade : IEA:Ensembl positive regulation of protein kinase B signaling : IEA:Ensembl regulation of glucose metabolic process : IEA:Ensembl camera-type eye morphogenesis : IEA:Ensembl endodermal cell differentiation : IEA:Ensembl epithelial cell proliferation : IEA:Ensembl extracellular matrix organization : IBA:GO_Central positive regulation of cell-substrate adhesion : IEA:Ensembl brown fat cell differentiation : IEA:Ensembl cellular response to drug : IEA:Ensembl cellular response to insulin stimulus : IEA:Ensembl detection of oxidative stress : IEA:Ensembl fatty acid beta-oxidation : IEA:Ensembl gene expression : IEA:Ensembl glucose homeostasis : IEA:Ensembl glucose metabolic process : IEA:Ensembl low-density lipoprotein particle clearance : IEA:Ensembl negative regulation of blood pressure : IEA:Ensembl negative regulation of cold-induced thermogenesis : IEA:Ensembl negative regulation of DNA biosynthetic process : IEA:Ensembl negative regulation of ERK1 and ERK2 cascade : IEA:Ensembl negative regulation of fat cell differentiation : IEA:Ensembl negative regulation of gluconeogenesis : IEA:Ensembl negative regulation of granulocyte differentiation : IEA:Ensembl negative regulation of heterotypic cell-cell adhesion : IEA:Ensembl negative regulation of I-kappaB kinase/NF-kappaB signaling : IEA:Ensembl negative regulation of inflammatory response : IEA:Ensembl negative regulation of intracellular protein transport : IEA:Ensembl negative regulation of low-density lipoprotein particle receptor biosynthetic process : IEA:Ensembl negative regulation of macrophage derived foam cell differentiation : IEA:Ensembl negative regulation of macrophage differentiation : IEA:Ensembl negative regulation of MAP kinase activity : IEA:Ensembl negative regulation of metanephric mesenchymal cell migration : IEA:Ensembl negative regulation of phagocytosis : IEA:Ensembl negative regulation of platelet-derived growth factor receptor-alpha signaling pathway : IEA:Ensembl negative regulation of protein autophosphorylation : IEA:Ensembl negative regulation of receptor binding : IEA:Ensembl negative regulation of synaptic transmission : IEA:Ensembl negative regulation of transcription, DNA-templated : IEA:Ensembl negative regulation of tumor necrosis factor production : IEA:Ensembl negative regulation of tumor necrosis factor-mediated signaling pathway : IEA:Ensembl negative regulation of vascular associated smooth muscle cell migration : IEA:Ensembl negative regulation of vascular smooth muscle cell proliferation : IEA:Ensembl positive regulation of cAMP-dependent protein kinase activity : IEA:Ensembl positive regulation of cholesterol efflux : IEA:Ensembl positive regulation of cold-induced thermogenesis : IEA:Ensembl positive regulation of fatty acid metabolic process : IEA:Ensembl positive regulation of glucose import : IEA:Ensembl positive regulation of I-kappaB kinase/NF-kappaB signaling : IEA:Ensembl positive regulation of interleukin-8 production : IEA:Ensembl positive regulation of metanephric glomerular visceral epithelial cell development : IEA:Ensembl positive regulation of monocyte chemotactic protein-1 production : IEA:Ensembl positive regulation of myeloid cell apoptotic process : IEA:Ensembl positive regulation of protein kinase A signaling : IEA:Ensembl positive regulation of renal albumin absorption : IEA:Ensembl protein localization to plasma membrane : IEA:Ensembl response to bacterium : IEA:Ensembl response to glucose : IEA:Ensembl response to tumor necrosis factor : IEA:Ensembl negative regulation of granulocyte differentiation : IEA:Ensembl negative regulation of macrophage differentiation : IEA:Ensembl synapse pruning : IEA:Ensembl metaphase plate congression : IBA:GO_Central positive regulation of protein localization to kinetochore : IBA:GO_Central complement activation, classical pathway : IEA:InterPro

Back

^{(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.}
^{(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.}