Heat shock protein 105 kDa (Q92598)

Uniprot ID Q92598
Protein Name Heat shock protein 105 kDa
Gene Name HSPH1
Species Homo sapiens (Human)
Signal peptide(a) N Secretome P(b)
Function Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (PubMed:24318877). Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity). .
GO - Molecular function
  • adenyl-nucleotide exchange factor activity : IDA:UniProtKB
  • alpha-tubulin binding : IEA:Ensembl
  • ATP binding : IEA:UniProtKB-KW
GO - Biological process
  • chaperone cofactor-dependent protein refolding : IEA:Ensembl
  • positive regulation of MHC class I biosynthetic process : TAS:BHF-UCL
  • positive regulation of NK T cell activation : TAS:BHF-UCL
  • receptor-mediated endocytosis : TAS:Reactome
  • regulation of cellular response to heat : TAS:Reactome
  • response to unfolded protein : TAS:ProtInc
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.