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Q92598

Heat shock protein 105 kDa (Q92598)

Uniprot ID Q92598
Protein Name Heat shock protein 105 kDa
Gene Name HSPH1
Species Homo sapiens (Human)
Basic Information Experiments (0) Disease (0) Interactions
Signal peptide(a) N Secretome P(b)
Function Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (PubMed:24318877). Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity). .
GO - Molecular function
  • adenyl-nucleotide exchange factor activity : IDA:UniProtKB
  • alpha-tubulin binding : IEA:Ensembl
  • ATP binding : IEA:UniProtKB-KW
GO - Biological process
  • chaperone cofactor-dependent protein refolding : IEA:Ensembl
  • positive regulation of MHC class I biosynthetic process : TAS:BHF-UCL
  • positive regulation of NK T cell activation : TAS:BHF-UCL
  • receptor-mediated endocytosis : TAS:Reactome
  • regulation of cellular response to heat : TAS:Reactome
  • response to unfolded protein : TAS:ProtInc
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.