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Q923D2

Flavin reductase (NADPH) (Q923D2)

Uniprot ID Q923D2
Protein Name Flavin reductase (NADPH)
Gene Name Blvrb
Species Mus musculus (Mouse)
Basic Information Experiments (3) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.84
Function Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin. .
GO - Molecular function
  • biliverdin reductase activity : ISS:UniProtKB
  • riboflavin reductase (NADPH) activity : ISS:UniProtKB
GO - Biological process
  • heme catabolic process : ISS:UniProtKB
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.