Protein disulfide-isomerase A6 (Q922R8)

Uniprot ID Q922R8
Protein Name Protein disulfide-isomerase A6
Gene Name Pdia6
Species Mus musculus (Mouse)
Signal peptide(a) Y Secretome P(b) 0.0
Function May function as a chaperone that inhibits aggregation of misfolded proteins (PubMed:24508390). Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling (By similarity). May also regulate the UPR via the EIF2AK3 UPR sensor (By similarity). Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin (By similarity). .
GO - Molecular function
  • peptide disulfide oxidoreductase activity : ISO:MGI
  • protein disulfide isomerase activity : ISS:UniProtKB
GO - Biological process
  • apoptotic cell clearance : IBA:GO_Central
  • cell redox homeostasis : IEA:InterPro
  • platelet activation : ISS:UniProtKB
  • platelet aggregation : ISS:UniProtKB
  • protein folding : IBA:GO_Central
  • response to endoplasmic reticulum stress : IBA:GO_Central
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.