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Q921M3

Splicing factor 3B subunit 3 (Q921M3)

Uniprot ID Q921M3
Protein Name Splicing factor 3B subunit 3
Gene Name Sf3b3
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.582
Function Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron. .
GO - Molecular function
  • protein-containing complex binding : ISO:MGI
  • RNA binding : IBA:GO_Central
GO - Biological process
  • mRNA splicing, via spliceosome : ISS:UniProtKB
  • negative regulation of protein catabolic process : ISO:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.