Protein bicaudal D homolog 2 (Q921C5)

Uniprot ID Q921C5
Protein Name Protein bicaudal D homolog 2
Gene Name Bicd2
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b)
Function Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:11483508, PubMed:25035494, PubMed:24986880, PubMed:22956769). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form (PubMed:25962623). Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport via its interaction with RAB6A and recruitment of the dynein-dynactin motor complex (PubMed:12447383, PubMed:25962623). Contributes to nuclear and centrosomal positioning prior to mitotic entry through regulation of both dynein and kinesin-1. During G2 phase of the cell cycle, associates with RANBP2 at the nuclear pores and recruits dynein and dynactin to the nuclear envelope to ensure proper positioning of the nucleus relative to centrosomes prior to the onset of mitosis (PubMed:20386726). .
GO - Molecular function
  • cytoskeletal adaptor activity : IEA:InterPro
  • dynactin binding : IDA:UniProtKB
  • dynein complex binding : IDA:UniProtKB
  • dynein light intermediate chain binding : IPI:FlyBase
  • Rab GTPase binding : IPI:BHF-UCL
GO - Biological process
  • centrosome localization : ISS:UniProtKB
  • microtubule anchoring at microtubule organizing center : IMP:BHF-UCL
  • microtubule-based movement : IDA:MGI
  • minus-end-directed organelle transport along microtubule : IMP:BHF-UCL
  • mRNA transport : IEA:UniProtKB-KW
  • protein localization to Golgi apparatus : IMP:UniProtKB
  • protein transport : IEA:UniProtKB-KW
  • regulation of microtubule cytoskeleton organization : ISO:MGI
  • retrograde vesicle-mediated transport, Golgi to ER : IMP:UniProtKB
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.