| Signal peptide(a) |
Y |
Secretome P(b) |
0.0 |
| Function |
Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development (PubMed:1423604). Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission. Acts as an alpha-2-macroglobulin receptor (By similarity). .(Microbial infection) Functions as a receptor for Vibrio cholerae cholix toxin and for Pseudomonas aeruginosa exotoxin A. {ECO:0000269|PubMed:1618748, ECO:0000269|PubMed:18276581}. |
| GO - Molecular function |
- alpha-2 macroglobulin receptor activity : ISS:UniProtKB
- apolipoprotein binding : ISO:MGI
- calcium ion binding : IDA:UniProtKB
- clathrin heavy chain binding : ISO:MGI
- protease binding : ISO:MGI
- protein-containing complex binding : ISO:MGI
|
| GO - Biological process |
- amyloid-beta clearance : IMP:BHF-UCL
- aorta morphogenesis : IMP:BHF-UCL
- apoptotic cell clearance : IMP:MGI
- cardiac septum development : IMP:MGI
- cell proliferation : ISO:MGI
- cholesterol metabolic process : IMP:MGI
- coronary vasculature development : IMP:MGI
- negative regulation of neuron apoptotic process : ISO:MGI
- negative regulation of neuron projection development : ISO:MGI
- negative regulation of platelet-derived growth factor receptor-beta signaling pathway : IMP:BHF-UCL
- negative regulation of smooth muscle cell migration : IMP:BHF-UCL
- negative regulation of Wnt signaling pathway : IDA:MGI
- positive regulation of cell death : ISO:MGI
- positive regulation of cholesterol efflux : IMP:BHF-UCL
- positive regulation of endocytosis : ISO:MGI
- positive regulation of lipid transport : IMP:BHF-UCL
- positive regulation of lysosomal protein catabolic process : ISO:MGI
- positive regulation of protein binding : ISO:MGI
- positive regulation of protein localization to plasma membrane : ISO:MGI
- positive regulation of protein transport : ISO:MGI
- protein kinase C-activating G-protein coupled receptor signaling pathway : ISO:MGI
- receptor-mediated endocytosis : IDA:MGI
- regulation of actin cytoskeleton organization : IMP:BHF-UCL
- regulation of cholesterol transport : IMP:BHF-UCL
- regulation of phospholipase A2 activity : IMP:BHF-UCL
- transcytosis : ISO:MGI
|