Home Proteins Experiments Diseases Interactions Tutorial
Home
/
Proteins
/
Q91YR9

Prostaglandin reductase 1 (Q91YR9)

Uniprot ID Q91YR9
Protein Name Prostaglandin reductase 1
Gene Name Ptgr1
Species Mus musculus (Mouse)
Basic Information Experiments (2) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.567
Function Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Has no activity towards PGE1, PGE2 and PGE2-alpha. Catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4 (By similarity). .
GO - Molecular function
  • 13-prostaglandin reductase activity : IEA:UniProtKB-EC
  • 15-oxoprostaglandin 13-oxidase activity : IEA:UniProtKB-EC
  • 2-alkenal reductase [NAD(P)] activity : IEA:UniProtKB-EC
GO - Biological process
  • response to antineoplastic agent : IEA:Ensembl
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.