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Q91V92

ATP-citrate synthase (Q91V92)

Uniprot ID Q91V92
Protein Name ATP-citrate synthase
Gene Name Acly
Species Mus musculus (Mouse)
Basic Information Experiments (3) Disease (2) Interactions
Signal peptide(a) N Secretome P(b) 0.554
Function ATP-citrate synthase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine (By similarity). .
GO - Molecular function
  • ATP binding : IEA:UniProtKB-KW
  • ATP citrate synthase activity : ISS:BHF-UCL
  • cofactor binding : IEA:InterPro
  • metal ion binding : IEA:UniProtKB-KW
GO - Biological process
  • acetyl-CoA biosynthetic process : ISS:BHF-UCL
  • acetyl-CoA metabolic process : ISO:MGI
  • citrate metabolic process : ISS:BHF-UCL
  • fatty acid biosynthetic process : ISO:MGI
  • lipid biosynthetic process : ISS:UniProtKB
  • oxaloacetate metabolic process : ISS:BHF-UCL
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.