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Q8VHX6

Filamin-C (Q8VHX6)

Uniprot ID Q8VHX6
Protein Name Filamin-C
Gene Name Flnc
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.434
Function Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross-linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers. .
GO - Molecular function
  • actin binding : TAS:MGI
  • actin filament binding : IEA:InterPro
  • ankyrin binding : ISO:MGI
  • cytoskeletal protein binding : ISO:MGI
  • identical protein binding : ISO:MGI
GO - Biological process
  • actin filament-based process : TAS:MGI
  • muscle fiber development : IDA:UniProtKB
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.