Aminopeptidase B (Q8VCT3)

Uniprot ID Q8VCT3
Protein Name Aminopeptidase B
Gene Name Rnpep
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b) 0.672
Function Exopeptidase which selectively removes arginine and/or lysine residues from the N-terminus of several peptide substrates including Arg(0)-Leu-enkephalin, Arg(0)-Met-enkephalin and Arg(-1)-Lys(0)-somatostatin-14. Can hydrolyze leukotriene A4 (LTA-4) into leukotriene B4 (LTB-4) (By similarity). .
GO - Molecular function
  • aminopeptidase activity : ISS:UniProtKB
  • cobalt ion binding : ISO:MGI
  • copper ion binding : ISO:MGI
  • metalloaminopeptidase activity : ISO:MGI
  • peptide binding : ISO:MGI
  • zinc ion binding : ISO:MGI
GO - Biological process
  • negative regulation of blood pressure : ISO:MGI
  • peptide catabolic process : IBA:GO_Central
  • proteolysis : ISO:MGI
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.