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Q8K1B8

Fermitin family homolog 3 (Q8K1B8)

Uniprot ID Q8K1B8
Protein Name Fermitin family homolog 3
Gene Name Fermt3
Species Mus musculus (Mouse)
Basic Information Experiments (2) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.432
Function Plays a central role in cell adhesion in hematopoietic cells (By similarity). Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3) (PubMed:18278053). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells (PubMed:19234461). Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (PubMed:18278053). .
GO - Molecular function
  • integrin binding : IDA:UniProtKB
GO - Biological process
  • integrin activation : IMP:UniProtKB
  • integrin-mediated signaling pathway : ISS:UniProtKB
  • leukocyte cell-cell adhesion : IMP:UniProtKB
  • platelet aggregation : IMP:UniProtKB
  • positive regulation of cell migration : ISS:UniProtKB
  • regulation of cell-cell adhesion mediated by integrin : IMP:UniProtKB
  • substrate adhesion-dependent cell spreading : ISS:UniProtKB
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.