Macrophage colony-stimulating factor 1 (Q8JZQ0)

Uniprot ID Q8JZQ0
Protein Name Macrophage colony-stimulating factor 1
Gene Name Csf1
Species Rattus norvegicus (Rat)
Signal peptide(a) Y Secretome P(b) 0.391
Function Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance (By similarity). .
GO - Molecular function
  • cytokine activity : ISO:RGD
  • growth factor activity : ISO:RGD
  • identical protein binding : IPI:RGD
  • macrophage colony-stimulating factor receptor binding : ISO:RGD
  • protein homodimerization activity : ISO:RGD
GO - Biological process
  • branching involved in mammary gland duct morphogenesis : ISO:RGD
  • cell population proliferation : IDA:RGD
  • developmental process involved in reproduction : ISO:RGD
  • homeostasis of number of cells within a tissue : ISO:RGD
  • inflammatory response : IEA:UniProtKB-KW
  • innate immune response : IEA:UniProtKB-KW
  • macrophage colony-stimulating factor signaling pathway : ISO:RGD
  • macrophage differentiation : IDA:RGD
  • mammary duct terminal end bud growth : ISO:RGD
  • mammary gland fat development : ISO:RGD
  • microglial cell proliferation : ISO:RGD
  • negative regulation of neuron death : ISO:RGD
  • odontogenesis : IMP:RGD
  • ossification : IMP:RGD
  • osteoclast differentiation : IMP:RGD
  • osteoclast proliferation : ISO:RGD
  • positive regulation of cell migration : ISO:RGD
  • positive regulation of cell population proliferation : ISO:RGD
  • positive regulation of cell-matrix adhesion : ISO:RGD
  • positive regulation of cellular protein metabolic process : ISO:RGD
  • positive regulation of gene expression : ISO:RGD
  • positive regulation of macrophage chemotaxis : ISO:RGD
  • positive regulation of macrophage colony-stimulating factor signaling pathway : ISO:RGD
  • positive regulation of macrophage derived foam cell differentiation : ISO:RGD
  • positive regulation of macrophage differentiation : ISO:RGD
  • positive regulation of microglial cell migration : ISO:RGD
  • positive regulation of monocyte differentiation : ISO:RGD
  • positive regulation of mononuclear cell proliferation : ISO:RGD
  • positive regulation of multicellular organism growth : ISO:RGD
  • positive regulation of odontogenesis of dentin-containing tooth : ISO:RGD
  • positive regulation of osteoclast differentiation : ISO:RGD
  • positive regulation of protein kinase activity : ISO:RGD
  • positive regulation of Ras protein signal transduction : ISO:RGD
  • regulation of ossification : ISO:RGD
  • response to ischemia : ISO:RGD
  • transmembrane receptor protein tyrosine kinase signaling pathway : ISO:RGD
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.