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Q8CIH5

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (Q8CIH5)

Uniprot ID Q8CIH5
Protein Name 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
Gene Name Plcg2
Species Mus musculus (Mouse)
Basic Information Experiments (2) Disease (3) Interactions
Signal peptide(a) N Secretome P(b) 0.366
Function The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling (By similarity). .
GO - Molecular function
  • phosphatidylinositol phospholipase C activity : ISS:UniProtKB
  • phospholipase C activity : TAS:MGI
  • phosphotyrosine residue binding : ISO:MGI
GO - Biological process
  • activation of store-operated calcium channel activity : IMP:MGI
  • B cell differentiation : IMP:UniProtKB
  • B cell receptor signaling pathway : IMP:UniProtKB
  • follicular B cell differentiation : IMP:MGI
  • inositol trisphosphate biosynthetic process : IDA:MGI
  • intracellular signal transduction : IEA:InterPro
  • negative regulation of programmed cell death : IMP:MGI
  • phosphatidylinositol biosynthetic process : ISS:UniProtKB
  • phospholipid catabolic process : IEA:InterPro
  • positive regulation of cytosolic calcium ion concentration : ISO:MGI
  • positive regulation of receptor internalization : IMP:CACAO
  • positive regulation of type I interferon production : IMP:CACAO
  • regulation of gene expression : IMP:MGI
  • release of sequestered calcium ion into cytosol : IMP:UniProtKB
  • response to ATP : ISO:MGI
  • response to lipopolysaccharide : IDA:MGI
  • response to magnesium ion : ISO:MGI
  • T cell receptor signaling pathway : IDA:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.