Thimet oligopeptidase (Q8C1A5)

Uniprot ID Q8C1A5
Protein Name Thimet oligopeptidase
Gene Name Thop1
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b) 0.0
Function Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation. Able to degrade the amyloid-beta precursor protein and generate amyloidogenic fragments (By similarity). .
GO - Molecular function
  • metal ion binding : IEA:UniProtKB-KW
  • metalloendopeptidase activity : IDA:MGI
  • peptidase activity : ISO:MGI
  • peptide binding : ISO:MGI
GO - Biological process
  • intracellular signal transduction : IDA:MGI
  • peptide metabolic process : IDA:MGI
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.