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Q8C115

Pleckstrin homology domain-containing family H member 2 (Q8C115)

Uniprot ID Q8C115
Protein Name Pleckstrin homology domain-containing family H member 2
Gene Name Plekhh2
Species Mus musculus (Mouse)
Basic Information Experiments (0) Disease (0) Interactions
Signal peptide(a) N Secretome P(b)
Function In the kidney glomerulus may play a role in linking podocyte foot processes to the glomerular basement membrane. May be involved in stabilization of F-actin by attenuating its depolymerization. Can recruit TGFB1I1 from focal adhesions to podocyte lamellipodia. .
GO - Molecular function
  • actin binding : IDA:UniProtKB
  • identical protein binding : IPI:IntAct
GO - Biological process
  • negative regulation of actin filament depolymerization : IDA:UniProtKB
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.