Autophagy-related protein 16-1 (Q8C0J2)

Uniprot ID Q8C0J2
Protein Name Autophagy-related protein 16-1
Gene Name Atg16l1
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b)
Function Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane (PubMed:18849966, PubMed:12665549, PubMed:24954904, PubMed:24553140, PubMed:23392225). Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production (By similarity). Negatively regulates NOD1-and NOD2-driven inflammatory cytokine response (PubMed:24238340). Instead, promotes with NOD2 an autophagy-dependent antibacterial pathway. Plays a role in regulating morphology and function of Paneth cell. .
GO - Molecular function
  • GTPase binding : ISO:MGI
  • identical protein binding : IPI:IntAct
GO - Biological process
  • autophagosome assembly : TAS:MGI
  • negative stranded viral RNA replication : IMP:MGI
  • protein lipidation involved in autophagosome assembly : IDA:MGI
  • protein localization to phagophore assembly site : IPI:MGI
  • protein transport : IEA:UniProtKB-KW
  • xenophagy : IPI:MGI
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.