| Signal peptide(a) |
N |
Secretome P(b) |
0.447 |
| Function |
Actin binding protein that promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins (By similarity). Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking. Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs (PubMed:17172441). Plays a role in platelets morphology through interaction with SYK that regulates ITAM-and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (PubMed:20713593). . |
| GO - Molecular function |
- actin binding : TAS:MGI
- actin filament binding : ISS:UniProtKB
- cadherin binding : ISO:MGI
- Fc-gamma receptor I complex binding : ISS:UniProtKB
- G-protein coupled receptor binding : ISO:MGI
- GTPase binding : ISO:MGI
- ion channel binding : ISO:MGI
- kinase binding : ISO:MGI
- mu-type opioid receptor binding : ISO:MGI
- potassium channel regulator activity : IMP:BHF-UCL
- protein homodimerization activity : ISO:MGI
- protein kinase C binding : IDA:MGI
- protein-containing complex binding : ISO:MGI
- Rac GTPase binding : ISS:UniProtKB
- Ral GTPase binding : ISO:MGI
- Rho GTPase binding : ISS:UniProtKB
- SMAD binding : ISO:MGI
- small GTPase binding : ISO:MGI
- transcription factor binding : ISS:UniProtKB
|
| GO - Biological process |
- actin crosslink formation : ISS:UniProtKB
- actin cytoskeleton organization : IGI:MGI
- actin cytoskeleton reorganization : ISS:UniProtKB
- adenylate cyclase-inhibiting dopamine receptor signaling pathway : ISS:UniProtKB
- angiogenesis : IMP:UniProtKB
- blood vessel remodeling : IMP:UniProtKB
- cell-cell junction organization : IMP:UniProtKB
- cilium assembly : ISO:MGI
- cytoplasmic sequestering of protein : ISS:UniProtKB
- early endosome to late endosome transport : IDA:MGI
- epithelial to mesenchymal transition : IGI:MGI
- establishment of protein localization : ISS:UniProtKB
- formation of radial glial scaffolds : ISO:MGI
- heart morphogenesis : IMP:UniProtKB
- mitotic spindle assembly : ISO:MGI
- mRNA transcription by RNA polymerase II : ISO:MGI
- negative regulation of apoptotic process : ISO:MGI
- negative regulation of DNA binding transcription factor activity : ISS:UniProtKB
- negative regulation of neuron projection development : IGI:WormBase
- negative regulation of protein catabolic process : ISS:UniProtKB
- negative regulation of transcription by RNA polymerase I : ISO:MGI
- positive regulation of I-kappaB kinase/NF-kappaB signaling : ISS:UniProtKB
- positive regulation of integrin-mediated signaling pathway : ISO:MGI
- positive regulation of neural precursor cell proliferation : ISO:MGI
- positive regulation of neuron migration : ISO:MGI
- positive regulation of potassium ion transmembrane transport : IMP:BHF-UCL
- positive regulation of substrate adhesion-dependent cell spreading : ISO:MGI
- protein localization to cell surface : ISS:UniProtKB
- protein localization to plasma membrane : IMP:BHF-UCL
- protein stabilization : ISS:UniProtKB
- receptor clustering : ISS:UniProtKB
- regulation of actin filament bundle assembly : IMP:UniProtKB
- regulation of cell migration : ISS:UniProtKB
- regulation of membrane repolarization during atrial cardiac muscle cell action potential : IC:BHF-UCL
- regulation of membrane repolarization during cardiac muscle cell action potential : IMP:BHF-UCL
- semaphorin-plexin signaling pathway : IGI:WormBase
- wound healing, spreading of cells : ISS:UniProtKB
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