Filamin-A (Q8BTM8)

Uniprot ID Q8BTM8
Protein Name Filamin-A
Gene Name Flna
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b) 0.447
Function Actin binding protein that promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins (By similarity). Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking. Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs (PubMed:17172441). Plays a role in platelets morphology through interaction with SYK that regulates ITAM-and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (PubMed:20713593). .
GO - Molecular function
  • actin binding : TAS:MGI
  • actin filament binding : ISS:UniProtKB
  • cadherin binding : ISO:MGI
  • Fc-gamma receptor I complex binding : ISS:UniProtKB
  • G-protein coupled receptor binding : ISO:MGI
  • GTPase binding : ISO:MGI
  • ion channel binding : ISO:MGI
  • kinase binding : ISO:MGI
  • mu-type opioid receptor binding : ISO:MGI
  • potassium channel regulator activity : IMP:BHF-UCL
  • protein homodimerization activity : ISO:MGI
  • protein kinase C binding : IDA:MGI
  • protein-containing complex binding : ISO:MGI
  • Rac GTPase binding : ISS:UniProtKB
  • Ral GTPase binding : ISO:MGI
  • Rho GTPase binding : ISS:UniProtKB
  • SMAD binding : ISO:MGI
  • small GTPase binding : ISO:MGI
  • transcription factor binding : ISS:UniProtKB
GO - Biological process
  • actin crosslink formation : ISS:UniProtKB
  • actin cytoskeleton organization : IGI:MGI
  • actin cytoskeleton reorganization : ISS:UniProtKB
  • adenylate cyclase-inhibiting dopamine receptor signaling pathway : ISS:UniProtKB
  • angiogenesis : IMP:UniProtKB
  • blood vessel remodeling : IMP:UniProtKB
  • cell-cell junction organization : IMP:UniProtKB
  • cilium assembly : ISO:MGI
  • cytoplasmic sequestering of protein : ISS:UniProtKB
  • early endosome to late endosome transport : IDA:MGI
  • epithelial to mesenchymal transition : IGI:MGI
  • establishment of protein localization : ISS:UniProtKB
  • formation of radial glial scaffolds : ISO:MGI
  • heart morphogenesis : IMP:UniProtKB
  • mitotic spindle assembly : ISO:MGI
  • mRNA transcription by RNA polymerase II : ISO:MGI
  • negative regulation of apoptotic process : ISO:MGI
  • negative regulation of DNA binding transcription factor activity : ISS:UniProtKB
  • negative regulation of neuron projection development : IGI:WormBase
  • negative regulation of protein catabolic process : ISS:UniProtKB
  • negative regulation of transcription by RNA polymerase I : ISO:MGI
  • positive regulation of I-kappaB kinase/NF-kappaB signaling : ISS:UniProtKB
  • positive regulation of integrin-mediated signaling pathway : ISO:MGI
  • positive regulation of neural precursor cell proliferation : ISO:MGI
  • positive regulation of neuron migration : ISO:MGI
  • positive regulation of potassium ion transmembrane transport : IMP:BHF-UCL
  • positive regulation of substrate adhesion-dependent cell spreading : ISO:MGI
  • protein localization to cell surface : ISS:UniProtKB
  • protein localization to plasma membrane : IMP:BHF-UCL
  • protein stabilization : ISS:UniProtKB
  • receptor clustering : ISS:UniProtKB
  • regulation of actin filament bundle assembly : IMP:UniProtKB
  • regulation of cell migration : ISS:UniProtKB
  • regulation of membrane repolarization during atrial cardiac muscle cell action potential : IC:BHF-UCL
  • regulation of membrane repolarization during cardiac muscle cell action potential : IMP:BHF-UCL
  • semaphorin-plexin signaling pathway : IGI:WormBase
  • wound healing, spreading of cells : ISS:UniProtKB
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.