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Q8BGQ7

Alanine--tRNA ligase, cytoplasmic (Q8BGQ7)

Uniprot ID Q8BGQ7
Protein Name Alanine--tRNA ligase, cytoplasmic
Gene Name Aars
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (5) Interactions
Signal peptide(a) N Secretome P(b) 0.449
Function Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. .
GO - Molecular function
  • alanine-tRNA ligase activity : IDA:UniProtKB
  • amino acid binding : ISO:MGI
  • aminoacyl-tRNA editing activity : IDA:UniProtKB
  • ATP binding : ISO:MGI
  • metal ion binding : IEA:UniProtKB-KW
  • tRNA binding : ISO:MGI
GO - Biological process
  • alanyl-tRNA aminoacylation : IDA:UniProtKB
  • cerebellar Purkinje cell layer development : IMP:MGI
  • negative regulation of neuron apoptotic process : IMP:MGI
  • neuromuscular process : IMP:MGI
  • neuromuscular process controlling balance : IMP:MGI
  • tRNA modification : IMP:MGI
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.