Filamin-B (Q80X90)

Uniprot ID Q80X90
Protein Name Filamin-B
Gene Name Flnb
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b) 0.454
Function Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton (By similarity). .
GO - Molecular function
  • actin binding : IEA:UniProtKB-KW
  • cadherin binding : ISO:MGI
  • identical protein binding : ISO:MGI
GO - Biological process
  • actin cytoskeleton organization : IMP:MGI
  • cellular response to interferon-gamma : IDA:MGI
  • epithelial cell morphogenesis : IMP:MGI
  • keratinocyte development : IMP:MGI
  • skeletal muscle tissue development : IDA:MGI
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.