Signal peptide(a) |
N |
Secretome P(b) |
0.908 |
Function |
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type. . |
GO - Molecular function |
- amyloid-beta binding : IDA:MGI
- carbohydrate binding : IDA:MGI
- ubiquitin-protein transferase activity : ISO:MGI
|
GO - Biological process |
- glycoprotein catabolic process : IDA:UniProtKB
- negative regulation of cell proliferation : ISO:MGI
- protein ubiquitination : IDA:UniProtKB
- regulation of protein ubiquitination : IDA:MGI
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process : IDA:UniProtKB
- ubiquitin-dependent ERAD pathway : IDA:MGI
- ubiquitin-dependent protein catabolic process : IDA:MGI
|