F-box only protein 2 (Q80UW2)

Uniprot ID Q80UW2
Protein Name F-box only protein 2
Gene Name Fbxo2
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b) 0.908
Function Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type. .
GO - Molecular function
  • amyloid-beta binding : IDA:MGI
  • carbohydrate binding : IDA:MGI
  • ubiquitin-protein transferase activity : ISO:MGI
GO - Biological process
  • glycoprotein catabolic process : IDA:UniProtKB
  • negative regulation of cell proliferation : ISO:MGI
  • protein ubiquitination : IDA:UniProtKB
  • regulation of protein ubiquitination : IDA:MGI
  • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process : IDA:UniProtKB
  • ubiquitin-dependent ERAD pathway : IDA:MGI
  • ubiquitin-dependent protein catabolic process : IDA:MGI
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.