Alpha-actinin-1 (Q7TPR4)

Uniprot ID Q7TPR4
Protein Name Alpha-actinin-1
Gene Name Actn1
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b) 0.528
Function F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity). .
GO - Molecular function
  • actin filament binding : IDA:UniProtKB
  • calcium ion binding : IEA:InterPro
  • double-stranded RNA binding : ISO:MGI
  • integrin binding : IPI:UniProtKB
  • ion channel binding : ISO:MGI
  • ligand-dependent nuclear receptor transcription coactivator activity : ISO:MGI
  • protein domain specific binding : ISO:MGI
  • protein homodimerization activity : IDA:UniProtKB
  • vinculin binding : IDA:UniProtKB
GO - Biological process
  • actin crosslink formation : IEA:InterPro
  • actin filament bundle assembly : IDA:UniProtKB
  • actin filament network formation : ISO:MGI
  • actin filament organization : ISO:MGI
  • cortical cytoskeleton organization : TAS:UniProtKB
  • focal adhesion assembly : ISO:MGI
  • negative regulation of cellular component movement : ISO:MGI
  • platelet formation : ISO:MGI
  • platelet morphogenesis : ISO:MGI
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.